| Title | A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Sung, YJu, Fuentes, Lde Las, Winkler, TW, Chasman, DI, Bentley, AR, Kraja, AT, Ntalla, I, Warren, HR, Guo, X, Schwander, K, Manning, AK, Brown, MR, Aschard, H, Feitosa, MF, Franceschini, N, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Marten, J, Musani, SK, Kilpeläinen, TO, Richard, MA, Aslibekyan, S, Bartz, TM, Dorajoo, R, Li, C, Liu, Y, Rankinen, T, Smith, AVernon, Tajuddin, SM, Tayo, BO, Zhao, W, Zhou, Y, Matoba, N, Sofer, T, Alver, M, Amini, M, Boissel, M, Chai, JFang, Chen, X, Divers, J, Gandin, I, Gao, C, Giulianini, F, Goel, A, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Jackson, AU, Kammerer, CM, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lee, W-J, Lin, K-H, Luan, J'an, Lyytikäinen, L-P, McKenzie, CA, Nelson, CP, Noordam, R, Scott, RA, Sheu, WHH, Stančáková, A, Takeuchi, F, van der Most, PJ, Varga, TV, Waken, RJ, Wang, H, Wang, Y, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Zhang, W, Zhao, JHua, Afaq, S, Alfred, T, Amin, N, Arking, DE, Aung, T, R Barr, G, Bielak, LF, Boerwinkle, E, Bottinger, EP, Braund, PS, Brody, JA, Broeckel, U, Cade, B, Campbell, A, Canouil, M, Chakravarti, A, Cocca, M, Collins, FS, Connell, JM, de Mutsert, R, H de Silva, J, Dörr, M, Duan, Q, Eaton, CB, Ehret, G, Evangelou, E, Faul, JD, Forouhi, NG, Franco, OH, Friedlander, Y, Gao, H, Gigante, B, C Gu, C, Gupta, P, Hagenaars, SP, Harris, TB, He, J, Heikkinen, S, Heng, C-K, Hofman, A, Howard, BV, Hunt, SC, Irvin, MR, Jia, Y, Katsuya, T, Kaufman, J, Kerrison, ND, Khor, CChuen, Koh, W-P, Koistinen, HA, Kooperberg, CB, Krieger, JE, Kubo, M, Kutalik, Z, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, JH, Lehne, B, Levy, D, Lewis, CE, Li, Y, Lim, SHui, Liu, C-T, Liu, J, Liu, J, Liu, Y, Loh, M, Lohman, KK, Louie, T, Mägi, R, Matsuda, K, Meitinger, T, Metspalu, A, Milani, L, Momozawa, Y, Mosley, TH, Nalls, MA, Nasri, U, O'Connell, JR, Ogunniyi, A, Palmas, WR, Palmer, ND, Pankow, JS, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Porteous, D, Raitakari, OT, Renstrom, F, Rice, TK, Ridker, PM, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Sabanayagam, C, Salako, BL, Sandow, K, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Sims, M, Sitlani, CM, Smith, BH, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tang, H, Taylor, KD, Teo, YYing, Tham, YChung, Uitterlinden, AG, Waldenberger, M, Wang, L, Wang, YXing, Bin Wei, W, Wilson, G, Wojczynski, MK, Xiang, Y-B, Yao, J, Yuan, J-M, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Chen, Y-DIda, Weir, DR, de Faire, U, Deary, IJ, Esko, T, Farrall, M, Forrester, T, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BLessa, Hung, Y-J, Jonas, JBruno, Kato, N, Kooner, JS, Laakso, M, Lehtimäki, T, Liang, K-W, Magnusson, PKE, Oldehinkel, AJ, Pereira, AC, Perls, T, Rauramaa, R, Redline, S, Rettig, R, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wareham, NJ, Watkins, H, Wickremasinghe, AR, Wu, T, Kamatani, Y, Laurie, CC, Bouchard, C, Cooper, RS, Evans, MK, Gudnason, V, Hixson, J, Kardia, SLR, Kritchevsky, SB, Psaty, BM, van Dam, RM, Arnett, DK, Mook-Kanamori, DO, Fornage, M, Fox, ER, Hayward, C, van Duijn, CM, E Tai, S, Wong, TYin, Loos, RJF, Reiner, AP, Rotimi, CN, Bierut, LJ, Zhu, X, L Cupples, A, Province, MA, Rotter, JI, Franks, PW, Rice, K, Elliott, P, Caulfield, MJ, W Gauderman, J, Munroe, PB, Rao, DC, Morrison, AC |
| Corporate Authors | LifeLines Cohort Study |
| Journal | Hum Mol Genet |
| Volume | 28 |
| Issue | 15 |
| Pagination | 2615-2633 |
| Date Published | 2019 Aug 01 |
| ISSN | 1460-2083 |
| Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Antiporters, Arterial Pressure, Blood Pressure, Caspase 9, Ethnicity, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Hypertension, Male, Membrane Proteins, Middle Aged, Polymorphism, Genetic, Racial Groups, Receptors, Vasopressin, Smoking, Sulfate Transporters, Tumor Suppressor Proteins, Young Adult |
| Abstract | Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P |
| DOI | 10.1093/hmg/ddz070 |
| Alternate Journal | Hum Mol Genet |
| PubMed ID | 31127295 |
| PubMed Central ID | PMC6644157 |
| Grant List | FS/12/82/29736 / BHF_ / British Heart Foundation / United Kingdom R01 HL103612 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom R01 HL086694 / HL / NHLBI NIH HHS / United States MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom G0401527 / MRC_ / Medical Research Council / United Kingdom U01 AG023746 / AG / NIA NIH HHS / United States G0500300 / MRC_ / Medical Research Council / United Kingdom T32 DK091317 / DK / NIDDK NIH HHS / United States BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom U01 HL120393 / HL / NHLBI NIH HHS / United States MC_EX_MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom K25 HL121091 / HL / NHLBI NIH HHS / United States R01 HL119443 / HL / NHLBI NIH HHS / United States R01 HL118305 / HL / NHLBI NIH HHS / United States R01 DK062370 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States G9521010 / MRC_ / Medical Research Council / United Kingdom G1000143 / MRC_ / Medical Research Council / United Kingdom R01 AG055406 / AG / NIA NIH HHS / United States MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom MR/K002414/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom U01 DK062370 / DK / NIDDK NIH HHS / United States MC_UP_1605/7 / MRC_ / Medical Research Council / United Kingdom 14136 / CRUK_ / Cancer Research UK / United Kingdom K01 HL135405 / HL / NHLBI NIH HHS / United States MC_PC_14089 / MRC_ / Medical Research Council / United Kingdom |
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
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